Dementia

Volume 5, Issue 3, November December 2010; Article-005 ISSN 0976 044X Research Article minocycline IMPROVES MEMORY IN MORRIS WATER MAZE TASK IN INTRACEREBROVENTRICULAR STREPTOZOTOCIN INFUSED RATS Vivek Kumar Sharma1* and Ashok Kumar Goyal2 * Govt. College of Pharmacy, Rohru, Dist. Shimla-171207, Himachal Pradesh,India 2 Onkar College of Pharmacy, Sunam, Dist. Sangrur, Punjab, India *Corresponding authors E-mail: viveksharma_pharma@yahoo.co.in 1 receive on: 21-10-2010; Finalized on: 14-12-2010. ABSTRACT In the account study, the aftermath of minocycline was studied against intracerebroventricular streptozotocin generate spatial interject dearth. manful wistar rats were injected with intracerebroventricular streptozotocin bilaterally. The rats were treated chronically with Minocycline (10, 20 and 40 mg/kg, ip) for 17 days starting from day 1 of streptozotocin gibe in separate groups. The spatial memory was evaluated victimisation the Morris wet maze task. The i ntracerebroventricular streptozotocin infused rats showed material memory deficits and minocycline showed significant dose dependent improvement in the task. The study exhibit the effectualness of minocycline in preventing spatial memory deficit induced by streptozotocin and its potential in age relate neurodegenerative dis hunting lodges where memory impairment is involved such as Alzheimers sickness. Keywords: Minocycline, spatial memory, ICV streptozotocin rats, Morris water maze. INTRODUCTION Alzheimers disease (AD) is a advancing neurodegenerative disorder with a mean age of around 8.5 old age between onset of clinical symptoms and death1. AD is the most vernacular cause of dementia in the elderly population. The most widely used treatment for Alzheimers disease at present are acetylcholinesterase inhibitors, which aim to elongate normal cognitive process through increased synaptic activity, without providing neuroprotection. This treatment is only characterist ic and provides modest outcomes...If you wan! t to subscribe to a full essay, order it on our website: OrderCustomPaper.com

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